Known safety concerns, contraindications, and risk factors.
Pregnancy and breastfeeding
Strictly contraindicated due to total lack of formal safety data for these populations.
Active seizure disorders
Melanocortin receptor modulation carries theoretical risk for CNS excitatory potential that could lower seizure thresholds.
Active psychotic disorders
Individuals with severe psychiatric instability or active psychosis should avoid Semax without strict medical supervision.
Concurrent stimulant medications (ADHD)
Semax potentiates D-amphetamine locomotor activity and dopamine release, significantly increasing stimulant effects and side effects.
Concurrent MAOI use
Theoretical risk of serotonin syndrome or unpredictable monoamine spikes. Human interactions not systematically studied.
Hypersensitivity to synthetic peptides
Users with known hypersensitivity to synthetic peptides or specific formulation components should avoid use.