Protocol Reference — Semax

Safe-Default Cycle

10–14 days

Standard cognitive enhancement cycle duration

Rest Period

10–20 days minimum

Preventative strategy to maintain receptor sensitivity; no clinical evidence of downregulation but cycling is standard practice

Dosing Frequency

1–2 doses per day

Intranasal, divided across morning and midday

Onset of Effect

Within hours (acute) to days (neurotrophic)

Acute cognitive effects appear quickly; BDNF upregulation builds over the cycle

Duration of Action

20–24 hours per dose

PGP tail extends biological activity well beyond plasma half-life