Protocol Reference — Tirzepatide

Initiation

2.5 mg SC weekly for 4 weeks

Starting dose. Do not skip the initiation period.

Step 2

5 mg SC weekly for 4 weeks

First efficacy dose. Assess GI tolerance before proceeding.

Step 3

7.5 mg SC weekly for 4 weeks

Intermediate dose. Many patients achieve adequate response here.

Step 4

10 mg SC weekly for 4 weeks

Assess weight loss trajectory and side effect profile.

Step 5 (maximum)

15 mg SC weekly (maintenance)

Maximum approved dose. Achieves 15-22.5% weight loss in trials. Extend any step beyond 4 weeks if GI tolerance is poor.

Missed dose rule

Administer if 4 days or fewer late; skip and resume schedule if more than 4 days late

Never double-dose.