Known safety concerns, contraindications, and age-stratified risk factors.
Pregnancy
High risk of virilising the female foetus. Absolute contraindication.
Known or Suspected Prostate/Breast Carcinoma
Androgens can stimulate the growth of hormone-sensitive tumours.
Uncontrolled Hypertension
Testosterone can further increase blood pressure, elevating MACE risk.
Severe Polycythaemia (Baseline Hematocrit >54%)
Exacerbates the risk of stroke or blood clots.
Concurrent Oral Anticoagulants
Androgens increase sensitivity to anticoagulants, raising bleeding risk.
Concurrent Insulin or Corticosteroids
Androgens decrease blood glucose (lowering insulin needs) and increase fluid retention when used with corticosteroids.