Posts tagged "peptides"

Increased Strength

From BPC-157 to MK-677, the new science of peptide-driven body recomposition is challenging the traditional anabolic toolkit.

The era of natural mimicry is here. Peptidomimetics designed to hijack endogenous signaling cascades offer accelerated tissue repair and metabolic correction — but the myostatin paradox, oncologic unknowns, and the regulatory cat-and-mouse game demand clinical caution over marketing hype.

increased strengthBPC-157MK-677AOD9604follistatin+7

Skin HealthOutcome

Skin Elasticity

Your skin loses 1% of its collagen every year after 20—but peptide signaling can tell your fibroblasts to rebuild what time has taken.

A deep dive into the peptide protocols that restore skin elasticity from the cellular level up. From copper peptides that reactivate collagen genes to telomere-protective compounds that extend the lifespan of dermal cells, this is the science of reversing structural skin aging.

skin-elasticity

NeuroprotectionOutcome

Neuroprotection

The peptide revolution promises to rewire your brain — but your immune system might have other plans.

An evidence-based exploration of neuroprotective peptides including GLP-1 receptor agonists, Selank, and Dihexa. We examine clinical promise alongside immunogenicity risks, grey-market purity concerns, and the thin line between neuroregeneration and oncogenic overstimulation.

neuroprotection

Cognitive HealthOutcome

Memory Management

From Dihexa's synaptogenic hammer to Cerebrolysin's clinical track record — five realities of the peptide cognition frontier, and the regulatory minefield around them.

An evidence-based exploration of memory-management peptides including Dihexa, Semax, Selank, P21, and Cerebrolysin. We examine synaptogenic potency claims alongside oncogenic risk, the FDA's 2024 compounding ban, and where clinical evidence ends and biohacking speculation begins.

memory-management

Cognitive HealthOutcome

Focus / ADHD

A clear-eyed map of the peptides and nutritional adjuncts being used for attention and executive function — what the literature supports, what the FDA has banned, and where the biohacking consensus is running ahead of the data.

An evidence-based exploration of focus and ADHD peptides including Semax, Selank, Noopept, Cerebrolysin and their nutritional adjuncts — with the regulatory, retraction and translational-gap landscape that the biohacking coverage tends to leave out.

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Cognitive HealthOutcome

Anxiety / Stress

An evidence-based map of synthetic glyprolines — Selank, Semax, NPY and Pinealon — peptides engineered to modulate the HPA axis and amygdala reactivity without the sedation, dependence or cognitive blunting of benzodiazepines.

A rigorous look at the neuropeptide approach to modern stress: the Pro-Gly-Pro stability trick, the GABAergic-but-not-sedative mechanism of Selank, Semax's ACTH-derived neuroprotection, the Russian clinical evidence base, and the FDA Category 2 constraint that defines legal reality in the US.

anxiety

Cellular HealthOutcome

Sleep Quality

Sleep is not a pause — it is the most active regenerative state your biology runs. The peptides here tune its architecture without sedating the system.

Most sleep aids work by suppressing the central nervous system. A small class of peptides — DSIP, Epitalon, and the CJC-1295 / Ipamorelin stack — take the opposite approach: they restore the body's own sleep rhythms, hormonal pulses, and cellular repair cycles. This is sleep as biological fine-tuning, not sedation.

sleep

PeptidesPeptide

BPC-157

A 15-amino-acid gastric pentadecapeptide that coordinates multi-system repair through angiogenesis, collagen synthesis, and gut-brain axis stabilization.

BPC-157 is a synthetic peptide derived from human gastric juice, notable for its extreme biochemical stability and capacity to coordinate tissue repair across musculoskeletal, vascular, and neurological systems.

bpc-157peptides

PeptidesPeptide

TB-500

A synthetic heptapeptide that acts as a molecular GPS for your body's repair crew — directing cell migration, building new blood vessels into injured tissue, and potentially re-activating embryonic healing pathways.

TB-500 is the synthetic analog of Thymosin Beta-4, a naturally occurring protein involved in actin regulation, cell migration, and tissue repair. Its unique mechanism targets the body's internal repair logistics rather than just providing raw materials.

tb-500

ResearchArticle

Protocol Support: Supplements

Peptides send the signal — but without the right micronutrient partners, the instruction falls flat. Here's the biochemistry behind why your protocol needs more than peptides.

Evidence-graded analysis of the micronutrient co-factors that determine whether peptide therapy delivers results — from Vitamin C and collagen synthesis to zinc and the IGF-1 axis, plus the contested evidence and research gaps the field still needs to close.

peptides

PeptidesPeptide

CJC-1295

A synthetic GHRH analog that tells your pituitary to release its own growth hormone, not inject someone else's.

CJC-1295 is a 29-amino acid GHRH analog engineered to resist enzymatic breakdown. It stimulates endogenous GH pulses rather than flooding the system with synthetic hormone, offering a fundamentally different risk-benefit profile to direct HGH therapy.

cjc-1295growth hormone

PeptidesPeptide

Ipamorelin

A selective ghrelin mimetic that triggers your pituitary to release growth hormone without touching cortisol, prolactin, or appetite.

Ipamorelin is a synthetic pentapeptide and the first truly selective growth hormone secretagogue. It binds the GHS-R1a receptor to trigger pulsatile GH release without the hormonal side-channel activation that defined earlier peptides like GHRP-6.

ipamorelingrowth hormone

PeptidesPeptide

KPV (Lysine-Proline-Valine)

KPV is the three-amino-acid tail of alpha-MSH: it keeps the parent hormone's anti-inflammatory power, drops the pigmentation, and targets inflamed tissue through the PepT1 transporter. The catch: every result so far is from cells or animals.

KPV (Lysine-Proline-Valine) is the C-terminal tripeptide of alpha-MSH, studied for anti-inflammatory, antimicrobial, gut, and skin applications. Evidence is entirely preclinical, with no completed human trials, and the compound is under FDA PCAC review for July 2026.

KPV

PeptidesPeptide

Cerebrolysin

Cerebrolysin is a porcine-brain peptide mixture sold as a master key for brain repair. It has decades of human trials, approval in 50+ countries, no FDA approval, and a Cochrane safety signal that complicates the story.

Cerebrolysin is a porcine-derived neurotrophic peptide preparation studied for stroke, TBI, and dementia. Human RCT data exists but is heterogeneous and industry-weighted, independent Cochrane reviews find no mortality benefit and a serious-adverse-event signal, and it is not FDA-approved.

Cerebrolysin

PeptidesPeptide

DSIP (Delta Sleep-Inducing Peptide)

DSIP was named for inducing delta sleep, but independent labs failed to replicate that in humans, no one has found its receptor or gene, and its best human stress trial found zero effect. Fascinating biology, unproven clinically.

DSIP (Delta Sleep-Inducing Peptide / Emideltide) is a nonapeptide studied for sleep, stress, and opioid withdrawal. Its human sleep data is inconsistent, its receptor is unknown, rodent stress effects failed to translate to humans, and it is not FDA-approved, with a PCAC review set for July 2026.

DSIP

peptides

peptides

Protocols

Increased Strength

Skin Elasticity

Neuroprotection

Memory Management

Focus / ADHD

Anxiety / Stress

Sleep Quality

BPC-157

TB-500

Protocol Support: Supplements

CJC-1295

Ipamorelin

KPV (Lysine-Proline-Valine)

Cerebrolysin

DSIP (Delta Sleep-Inducing Peptide)

Protocols

Increased Strength

Skin Elasticity

Neuroprotection

Memory Management

Focus / ADHD

Anxiety / Stress

Sleep Quality

BPC-157

TB-500

Protocol Support: Supplements

CJC-1295

Ipamorelin

KPV (Lysine-Proline-Valine)

Cerebrolysin

DSIP (Delta Sleep-Inducing Peptide)