Scheduling, administration, biomarkers, and practical guidance.
Safe-default for novice users; reduces risk of receptor desensitisation.
Anxiolytic-use cycling; allosteric GABAA modulation tolerance-builds without washout.
Weekly pause intended to blunt c-Met downregulation; no rigorous human validation.
Short, goal-bounded course rather than chronic use; based on preclinical kinetics.
Clinical standard from Guekht 2011 protocol — the most evidence-backed cycle in the class.
Before noon
Enhanced CNS activity interferes with sleep onset and architecture if dosed late in the day.
Morning administration preferred
Stimulant-like effect on cognition and mood; evening dosing risks disrupting sleep.
Can dose across the day
Anxiolytic without sedation; rapid half-life accommodates multiple daily administrations.
Daytime infusion
Clinical standard follows supervised daytime administration schedule.