Scheduling, administration, biomarkers, and practical guidance.
Continuous during active injury repair. No strict cycling required at beginner dose.
Split into 2 doses (500 mcg AM / 500 mcg PM). Inject near injury site when possible.
6 weeks on / 6 weeks off. Loading phase: first 2 weeks at full daily dose.
6 weeks on / 6 weeks off. May split into 2 daily injections for stable serum levels.
2-4 weeks on / 2-4 weeks off to prevent metabolic signaling desensitization.
2-4 weeks on / 2-4 weeks off. Monitor fasting glucose closely. Do not combine with extended fasting.
3-week cycles followed by extended off-periods (minimum 3 months between cycles).
Variable dosing. Requires baseline and follow-up telomere length testing. Screen for occult malignancy before starting.
Apply directly to target area. No cycling required for topical use.
4 weeks on / 2 weeks off. Monitor copper levels if using concurrently with copper supplements.
Schedule HBOT sessions on peptide injection days for synergistic angiogenesis. Allow 2-4 hours between HBOT and injection.
Short half-life benefits from twice-daily dosing to maintain stable tissue concentrations during repair.
Single daily dose is sufficient due to systemic distribution. Morning dosing aligns with natural circadian repair signaling.
AMPK activation and GLUT4 translocation are safest when glucose is available. Avoid fasted-state administration to prevent hypoglycemia.
Telomerase activity and cellular repair are upregulated during sleep. Evening dosing aligns with natural circadian DNA repair windows.
Collagen synthesis peaks during sleep. Evening administration supports overnight tissue remodeling.
Allows 2-4 hours before evening peptide doses. Oxygen saturation peaks benefit daytime activity and repair.