Protocol Reference — Anxiety / Stress

Selank cycle

10–14 days on / 7–14 days off

Empirical cycling protocol from Russian clinical practice; extended uncycled use is outside the evidence base.

Semax cycle

10–20 days on / 10–14 days off

Longer on-cycles are used for neuroprotective indications (stroke recovery); shorter cycles for anxiety/focus use.

Pinealon cycle

10-day intensive course, up to 2× per year

Not a daily maintenance compound. Used as targeted circadian resets.

NPY use pattern

Acute-only, single-dose

No evidence for chronic dosing. Used for situational acute anxiety, not maintenance.

Time-of-day — Semax

AM only

Afternoon or evening dosing drives insomnia and vivid dream disturbance in a meaningful fraction of users.

Time-of-day — Selank

Flexible, split 1–3×

Does not disrupt sleep; can be dosed through the day.