MK-677 (Ibutamoren)

Known safety concerns, contraindications, and risk factors.

Immediate Effects (4)

Long-Term Risks (3)

Sourcing Dangers (3)

Contraindications (4)

Diabetes, prediabetes, or metabolic syndrome

MK-677 consistently increases fasting glucose and HbA1c. Use in metabolically compromised individuals accelerates diabetic trajectory.

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Heart failure, ischaemic heart disease, or uncontrolled hypertension

GH-induced fluid retention increases cardiac preload. Clinical trial terminated early due to CHF signal in elderly patients.

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Active or suspected malignancy

Sustained IGF-1 elevation promotes cellular proliferation and could accelerate tumour growth.

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Concurrent CYP3A4 inhibitors or P-glycoprotein inhibitors

CYP3A4 inhibitors (ketoconazole, ritonavir) increase systemic exposure. P-gp inhibitors (amiodarone, verapamil) alter absorption.

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Auto-Generated Safety Flags

MK-677 is NOT FDA-approved for any indication and has no legal prescription or compounding pathway. Products sold for human use lack regulatory oversight.

A Phase IIb hip fracture trial was terminated early due to a congestive heart failure signal: 6.5% treatment versus 1.7% placebo. MK-677 is contraindicated in heart failure and uncontrolled hypertension.

MK-677 consistently increases fasting blood glucose and HbA1c. It is contraindicated in diabetes, prediabetes, and metabolic syndrome.

Sustained IGF-1 elevation promotes cell proliferation. MK-677 is contraindicated in individuals with active or suspected malignancy.

MK-677 increases fat-free mass but does NOT improve muscle strength or physical function. The lean mass gained is not equivalent to functional muscle.

MK-677 is metabolised by CYP3A4. Concurrent use with ketoconazole, ritonavir, or other CYP3A4 inhibitors increases systemic exposure.

MK-677 is banned by WADA (Category S2) and the Department of Defense. Use results in positive doping tests.

Grey market MK-677 products are frequently mislabelled, overdosed, or contaminated with SARMs. No pharmaceutical-grade product exists for human use.

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