Posts tagged "sleep"

Sleep Quality

Sleep is not a pause — it is the most active regenerative state your biology runs. The peptides here tune its architecture without sedating the system.

Most sleep aids work by suppressing the central nervous system. A small class of peptides — DSIP, Epitalon, and the CJC-1295 / Ipamorelin stack — take the opposite approach: they restore the body's own sleep rhythms, hormonal pulses, and cellular repair cycles. This is sleep as biological fine-tuning, not sedation.

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MK-677 (Ibutamoren)

The oral compound that reliably raises GH and IGF-1 to youthful levels, delivers measurable gains in lean mass and sleep architecture, yet consistently failed to translate those biomarker wins into functional outcomes across 30 years of clinical trials.

MK-677 (Ibutamoren) is a non-peptide, orally active growth hormone secretagogue that selectively agonises the ghrelin receptor (GHS-R1a). It increases 24-hour GH secretion by up to 97% and IGF-1 by 60-79%, producing verified gains in fat-free mass and sleep quality. However, the lean mass does not translate to strength, the bone turnover does not translate to density, and insulin resistance is a consistent pharmacological cost.

mk-677

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DSIP (Delta Sleep-Inducing Peptide)

DSIP was named for inducing delta sleep, but independent labs failed to replicate that in humans, no one has found its receptor or gene, and its best human stress trial found zero effect. Fascinating biology, unproven clinically.

DSIP (Delta Sleep-Inducing Peptide / Emideltide) is a nonapeptide studied for sleep, stress, and opioid withdrawal. Its human sleep data is inconsistent, its receptor is unknown, rodent stress effects failed to translate to humans, and it is not FDA-approved, with a PCAC review set for July 2026.

DSIP

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Protocols

Sleep Quality

MK-677 (Ibutamoren)

DSIP (Delta Sleep-Inducing Peptide)

Protocols

Sleep Quality

MK-677 (Ibutamoren)

DSIP (Delta Sleep-Inducing Peptide)