PT-141 (Bremelanotide)
The first FDA-approved peptide that targets the brain's desire circuitry instead of the body's vascular hardware, opening a new front in sexual medicine, appetite regulation, and central neuromodulation.
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and centrally acting melanocortin receptor agonist FDA-approved for premenopausal female HSDD. It bypasses peripheral blood flow entirely, activating MC3R and MC4R in the hypothalamus to trigger dopamine and oxytocin release. Emerging data positions it as a post-GLP-1 weight rebound shield and a rescue therapy for PDE5 inhibitor non-responders in men.
pt-141bremelanotidevyleesimelanocortinmc4r+5