Protocol Reference — Ipamorelin

Cycle Duration

12-16 weeks on

Both standalone and stack protocols

Rest Period

4-8 weeks off

Prevents pituitary receptor downregulation

Weekly Pattern (Option A)

Daily continuous

Simpler schedule, higher total exposure

Weekly Pattern (Option B)

5 days on / 2 days off

Brief receptor recovery within the cycle

Preferred Timing

30 minutes before bed, fasted

Aligns with natural nocturnal GH secretory peak

Fasting Window

2+ hours after last meal

Insulin suppresses GH release at the pituitary; fasting removes this competition